Correction of Pulmonary Abnormalities in Sftpd/ Mice Requires the Collagenous Domain of Surfactant Protein D
Surfactant protein D (SP-D) is a member of the collectin family of innate defense proteins. Members of this family share four distinct structural domains: an N-terminal crosslinking domain, a collagenous domain, a neck region, and a carbohydrate recognition domain. In this study, the function of the collagenous domain was evaluated by expressing a SP-D collagen …
Surfactant protein-D regulates the postnatal maturation of pulmonary surfactant lipid pool sizes
Surfactant protein (SP)-D plays an important role in host defense and pulmonary surfactant homeostasis. In SP-D-deficient (Sftpd−/−) mice, the abnormal large surfactant forms seen at the ultrastructural level are taken up inefficiently by type II cells, resulting in an over threefold increase in the surfactant pool size. The mechanisms by which SP-D influences surfactant ultrastructure …
Surfactant Protein-D Inhibits Lung Inflammation Caused by Ventilation in Premature Newborn Lambs
Rationale: Premature newborns frequently require manual ventilation for resuscitation during which lung injury occurs. Although surfactant protein (SP)-D regulates pulmonary inflammation, SP-D levels are low in the preterm lung. Commercial surfactants for treatment of respiratory distress syndrome do not contain SP-D. Objectives: To determine whether addition of recombinant human SP-D (rhSP-D) to commercial surfactant influences …
Surfactant Protein D Deficiency Increases Lung Injury during Endotoxemia
Acute lung injury (ALI) and its severe form, acute respiratory distress syndrome (ARDS), are major causes of acute respiratory failure with high rates of morbidity and mortality. Although surfactant protein (SP)-D plays a critical role in pulmonary innate immunity and several clinical studies suggest that this protein may be implicated in the pathophysiology of ARDS, …
Supramolecular Assembly of Human Pulmonary Surfactant Protein SP-D.
Pulmonary surfactant protein D (SP-D) is a glycoprotein from the collectin family that is a component of the lung surfactant system. It exhibits host defense and immune regulatory functions in addition to contributing to the homeostasis of the surfactant pool within the alveolar airspaces. It is known that the SP-D monomer forms trimers, which further …
Airway Therapeutics Announces Appointment of Chief Medical Officer
(Cincinnati, OH—August 24, 2018) Airway Therapeutics, LLC (“Airway”), a biotechnology company focused on developing new interventions for acute and chronic lung diseases, announces the appointment of Paul Kingma, MD, PhD to the position of Chief Medical Officer (“CMO”) as of August 1, 2018 in preparation for clinical development of AT-100, a recombinant form of human …
Airway Therapeutics Closes $11M Series B Round of Financing
(Cincinnati, OH– April 17, 2018) Airway Therapeutics, a biotechnology company focused on developing new interventions for acute and chronic lung diseases has secured $11 million in Series B financing from new and existing investors. The financing comes as Airway Therapeutics steadily meets milestones in the development of its lead product AT-100, a recombinant form of …
Airway Therapeutics, LLC Obtains License on Glycotope Cell Line
Core Manufacturing Technology is Key Milestone on Airway’s Path to Market Cincinnati, Ohio, 11 September 2017- Airway Therapeutics, LLC, [Airway] a biotech company focused on developing new interventions for acute and chronic lung diseases, today announced an exclusive licensing agreement with the German biotechnology company, Glycotope GmbH [Glycotope]. Under the terms of this agreement, Airway …
Airway Therapeutics Closes $6.3M in Finance Round
Financing furthers Company’s efforts to improve outcomes for very premature infants Cincinnati OH—March 6, 2017 Airway Therapeutics, a biotechnology company focused on developing new interventions for acute and chronic lung diseases, beginning with premature infants, has secured $6.3 million in bridge financing from new and existing investors. Cincinnati Children’s Hospital Medical Center, CincyTech and Queen …
